The Human P Histo-Blood Group Antigen Provides Protection Against HIV-1 Infection
نویسندگان
چکیده
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Canadian Blood Services, Toronto, Canada; Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University & University Hospital Blood Centre, Lund, Sweden; Magen David Adom National Blood Services, Ramat Gan, Israel; Department of Medicine, University of Toronto, Toronto, Canada; Division of Cell and Molecular Biology, Toronto General Research Institute of the University Health Network, Toronto, Ontario, M5G 2M1, Canada; Research Institute, Hospital for Sick Children, Toronto, Canada; Héma-Québec Research & Development, Québec, Canada; Laval University, Department of Microbiology and Biochemistry, Québec, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada.
منابع مشابه
The human P(k) histo-blood group antigen provides protection against HIV-1 infection.
Several human histo-blood groups are glycosphingolipids, including P/P1/P(k). Glycosphingolipids are implicated in HIV-host-cell-fusion and some bind to HIV-gp120 in vitro. Based on our previous studies on Fabry disease, where P(k) accumulates and reduces infection, and a soluble P(k) analog that inhibits infection, we investigated cell surface-expressed P(k) in HIV infection. HIV-1 infection o...
متن کاملTRANSFUSION MEDICINE The human Pk histo-blood group antigen provides protection against HIV-1 infection
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON; 2Canadian Blood Services, Toronto, ON; 3Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University & University Hospital Blood Centre, Lund, Sweden; 4Magen David Adom National Blood Services, Ramat Gan, Israel; 5Department of Medicine, University of Toronto, Toronto,...
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